Publications
Selected Publications
Barbieri EM, Linsenmeier M, Whiteman KR, Cheng Y, Braganza S, Copley KE, Castrodad PM, Lewis B, Villafane K, Amado DA, Davidson BL, Shorter J. Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity. bioRxiv May 2025.
Amado DA, Robbins AB, Whiteman KR, Smith AR, Chillon G, Chen Y, Fuller JA, Patty NA, Izda A, Cheng C, Nelson S, Dichter AI, Mazzoni EO, Monteys AM, Davidson BL. AAV-based delivery of RNAi targeting ataxin-2 improves survival and pathology in TDP-43 mice. Nature Communications June 2025.
Dratch L, Bardakjian TM, Johnson K, Babaian N, Gonzalez-Alegre P, Elman L, Quinn C, Guo MH, Scherer SS, Amado DA. The Importance of Offering Exome or Genome Sequencing in Adult Neuromuscular Clinics. Biology February 2024.
Amado DA, Robbins A. The Emerging Landscape of Targeted Therapeutics for Genetic Neuromuscular Disorders. Practical Neurology August 2023.
Dawicki-McKenna J, Felix A, Waxman E, Cheng C, Amado DA, Ranum P, Bogush A, Dungan L, Heller E, French D, Davidson BL, Prosser B. Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching. Nature Communications May 2023. PMCID: PMC10164156
Amado DA, Davidson BL. Gene therapy for ALS: A Review. Molecular Therapy May 2021. PMCID: PMC8636154
Mao F, Robinson J, Unger T, Amado DA, Elman L, Grossman M, Weintraub D, Wolk D, Lee E, Van Deerlin V, Porta SSs, Lee V, Trojanowski JQ, Chen-Plotkin AS. TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy. Acta Neuropathologica October 2021. PMCID: PMC8812793
Amado DA, Rieders JM, Diatta F, Hernandez-Con P, Singer A, Mak JT, Zhang J, Lancaster E, Davidson BL, Chen-Plotkin AS.: AAV-mediated progranulin delivery to a mouse model of progranulin deficiency causes T cell-mediated toxicity. Molecular Therapy 27(2): 465-478, February 2019. PMCID: PMC6369714
Amado D, Mingozzi F, Hui D, Bennicelli JL, Wei Z, Chen Y, Bote E, Grant RL, Golden JA, Narfstrom K, Syed NA, Orlin SE, High KA, Maguire AM, Bennett J.: Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness. Science Translational Medicine 2(21): 21ra16, March 2010. PMCID: PMC4169124
Other Publications
Masrori P, Amado DA. RAN translation as a dominant pathogenic axis in C9ORF72-associated ALS and FTD models. Molecular Neurodegeneration June 2026.
Spencer BE, Irwin D, VanDeerlin V, Suh E, Lee EB, Elman L, Quinn C, Amado DA, Baer M, Grossman M, Wolk D, McMillan C. Polygenic associations with clinical and neuropathological trait heterogeneity across TDP-43 proteinopathies. PLoS One December 2025.
Spencer BE, Xie SX, Ohm DT, Elman L, Quinn C, Amado DA, Baer M, Lee EB, van Deerlin VM, Dratch L, Massimo L, Irwin DJ, McMillan CT. Cumulative incidence of motor and cognitive features in the amyotrophic lateral sclerosis-frontotemporal degeneration spectrum. Brain Communications October 2025.
Quinn CQ, Baer M, Amado DA, Kelley M, Elman L. A Single ALS Center Experience with Clinical use of Sodium Phenylbutyrate-Taurursodiol. Muscle and Nerve May 2024.
Rhodes E, Alfa S, Jin H, Massimo L, Elman L, Amado DA, Baer M, Quinn C, McMillan CT. Cognitive reserve in ALS: The role of occupational skills and requirements. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration April 2024.
Baldwin A, Copeland J, Azage M, Dratch L, Johnson K, Paul RA, Amado DA, Baer M, Deik AF, Elman LB, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA. Disparities in genetic testing for neurologic disorders. Neurology March 2024.
Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon S, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA. Genetic testing in adults with neurological disorders: Indications, approach, and clinical impacts. Journal of Neurology February 2024.
Shellikeri S, Cho S, Ash S, Gonzalez-Recober C, McMillan C, Elman L, Quinn C, Amado DA, Baer M, Irwin DJ, Massimo L, Olm C, Liberman M, Grossman M, Nevler N. Digital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorder. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration December 2023.
Shen T, Vogel JW, Duda J, Phillips JS, Cook PA, Gee J, Elman L, Quinn C, Amado DA, Baer M, Massimo L, Grossman M, Irwin DJ, McMillan C. Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum. Translational Neurodegeneration December 2023.
Cousins KAQ, Shaw LM, Shellikeri S, Dratch L, Rosario L, Elman LB, Quinn C, Amado DA, Wolk DA, Tropea TF, Chen-Plotkin A, Irwin DJ, Grossman M, Lee EB, Trojanowski JQ, McMillan CT. Elevated Plasma Phosphorylated Tau 181 in Amyotrophic Lateral Sclerosis. Annals of Neurology July 2022. PMCID: PMC9588516
Bhatla A, Asmar M, Amado DA. Multiple streptococcal brain abscesses in a patient taking Secukinumab. Neurology Clinical Practice October 2021. PMCID: PMC8610518
Posavi M, Diaz-Ortiz M, Liu B, Swanson CR, Skrinak RT, Hernandez-Con P, Amado DA, Fullard M, Rick J, Siderowf A, Weintraub D, McCluskey L, Trojanowski JQ, Dewey RB Jr, Huang X, Chen-Plotkin AS.: Characterization of Parkinson's disease using blood-based biomarkers: A multicohort proteomic analysis. PLoS Medicine 16(10): e1002931, October 2019. PMCID: PMC6788685
Siegler JE, Jacobs DA, Amado D, Adams JL, Berger JR. : Rapidly progressive dementia with hypoglycorrhachia. Journal of Clinical Neuroscience 22(10): 1685-1687, October 2015.
Canver MC, Canver AC, Revere KE, Amado D, Bennett J, Chung DC. : Novel mathematical algorithm for pupillometric data analysis. Computer Methods and Programs in Biomedicine 113(10): 221-225, 2014.
Lukinova N, Iacovelli J, Dentchev T, Wolkow N, Hunter A, Amado D, Ying GS, Sparrow JR, Dunaief JL.: Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli. Investigative Ophthalmogy and Visual Science 50(3): 1440-1447, March 2009. PMCID: PMC2665187
Jaramillo AM, Zheng X, Zhou Y, Amado DA, Sheldon A, Sehgal A, Levitan IB.: Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila. BMC Neuroscience 5(3), January 2004. PMCID: PMC343274